Abstract:. The available conventional vaginal preparations of Benzydamine like vaginal douche and cream have drawbacks like less contact time, messy to apply, uncomfortable for patient, chances of inaccurate drug dosing in semisolid formulations due to non-uniform distribution in the vaginal cavity, poor retention at the site of action due to the self-cleansing action of the vaginal tract. In present study Bioadhesive Tablets were prepared using Carbopol 934 and HPMC. Benzydamine hydrochloride vaginal tablets were evaluated for various parameters like thickness(mm), Hardness (kg/cm2),Average weight (mg), % Drug Content, , % Friability, Effect on pH of medium, Swelling study, in- vitro bioadhesion study, in-vitro benzidamine release study and data treatment thereof. All the physical parameters were found to be satisfactory within the specified limits. It is shown that with the developed formulations, the Benzydamine release, % Swelling and bioadhesion properties of bioadhesive tablets can be controlled by changing polymer concentration and effervescent content. The best fit dissolution kinetic model for release of Benzydamine were found to be zero order kinetic model and Higuchi square root kinetic model. Former revelead that the mechanism of drug release does not depend on concentration of drug and same amount of drug is released per unit time. While Higuchi square root kinetic model showed that drug release occurs by diffusion from Carbopol 934 and HPMC polymer matrix. Bioadhesion of the developed formulations would provide a longer period of residence time. Drug polymer compatibility studies FTIR, DSC, were also carried out indicating no incompatibility between drug and polymers used.
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